Discover in this article the different side effects that can cause CBD. A preclinical study in the British Journal of Pharmacology stated that CBD might help alleviate vomiting & nausea caused by treatments, like chemo. Learn more.
What are the different potential side effects of CBD?
CBD is a natural product that is considered safe and consumable without negative health implications. The World Health Organization (WHO) has officially stated that CBD is neither harmful nor addictive.
When applied topically or taken orally, its effects are therapeutic and recommended for people wishing to relax, calm anxiety, or treat symptoms of illness.
There are some potential side effects to keep in mind when using this substance, however, the majority of which are mild. Each individual reacts differently to CBD and may develop a different reaction, positive or negative, depending on their body.
Among the most common side effects, CBD can cause nausea, drowsiness, dry mouth, gastrointestinal issues and a few other discomforts that fade with time and use.
In this article, let’s look in detail at the potential side effects of CBD on the body. Keep in mind that these side effects are not systematic and do not last over time.
What is cannabidiol (CBD)
Let’s briefly review what CBD is. This is important to understand how it works in the body and its effects. CBD, short for cannabidiol, is a compound from the hemp plant that has become very popular since 2014 according to internet research on the molecule.
CBD is thus one of many chemical compounds found in the cannabis plant, also known as cannabis sativa. The two main compounds found in cannabis are the well-known THC, or Tetrahydrocannabinol, and CBD, which has made a name for itself in recent years. Although they come from the same plant, THC and CBD are very different from each other. Let’s take a look at what sets them apart.
CBD and THC
In fact, THC is the psychoactive molecule that makes you “high” in cannabis. It is prohibited for consumption in France. CBD is classified as a non-harmful and non-psychoactive molecule because it contains less than 0.2% THC in its composition. Cannabis plants such as marijuana are grown to have high levels of THC and are illegal to grow, market and consume in France.
CBD is considered non-harmful and very good for your health. In fact, its therapeutic properties are useful in the natural treatment of symptoms of diseases with limited treatment resources such as Parkinson’s disease , Alzheimer’s , epilepsy , fibromyalgia etc.
The side effects of THC are obvious. They range from the euphoric effect for which it is best known, to much more limiting effects such as depression, anxiety, fear of death, paranoia, loss of control, hallucination etc.
The side effects of CBD are the opposite of THC. This is because CBD does not get stoned, which reduces the discomfort that CBD can potentially cause on its consumer. Let’s look at its side effects in detail.
The potential side effects of CBD
The most commonly reported side effects of CBD users include drowsiness, gastrointestinal problems, dry mouth, reduced appetite, nausea, results of interaction with other medications and fatigue. They are rare, mild and usually over a very short period of time.
Let’s look at them in detail below.
One of the common side effects when using CBD is drowsiness and sedation. Indeed, CBD is well known to be a product to take before going to bed as it is relaxing and can help with insomnia. This side effect is therefore considered an advantage for people who have difficulty sleeping. However, it is important to keep in mind that not all CBDs make you want to sleep. Some are very suitable for consumption in the morning. Read the directions on your products.
Some people may experience diarrhea or liver problems when using CBD. This depends a lot on the consumer and their medical history. This side effect is rare and only appears on a small portion of people who use CBD. If it appears, it must nevertheless be taken very seriously. If you have intestinal problems, do not hesitate to ask your doctor for advice before consuming CBD. He or she can help you set a dosage to avoid having these discomforts.
CBD can potentially make the mouth and eyes very dry. While this side effect is more likely to occur with THC, it can also occur with CBD as well. This dry mouth is caused by CBD’s action on the endocannabinoid receptors present in the salivary glands. You can calm this sensation quickly with a glass of water.
CBD is known to affect the level of serotonin that the body produces, and thus the cravings that it causes. By increasing serotonin levels naturally, the effect of CBD kind of replaces the pleasure effect that food might produce. We cannot yet say that CBD acts strongly on the appetite however, it is undeniable that it causes in some consumers this sensation of appetite reduction.
Fatigue is a very rare side effect of CBD that is usually seen by people with chronic fatigue syndrome. Therefore, it is possible that people predisposed to having fatigue may feel very tired when taking CBD.
Interaction with other medications
CBD could interfere with other medications you are taking. It’s important to talk to your doctor about whether CBD could affect your existing prescriptions. Check out our article: CBD and taking medication: Possible?
While CBD is known for its anti-inflammatory effects that are very good for nausea, gastritis, and other inflammation in the stomach, in some cases CBD-derived products can cause transient nausea. This effect depends greatly on the intestinal sensitivity and the physical and emotional state of the CBD user, as well as the quantity ingested. This side effect is rare and often due to a combination of factors including CBD intake, but is never due to CBD consumption alone.
How to prevent CBD side effects
First, don’t hesitate to talk to your doctor about these discomforts. If you already have prescriptions, your doctor will be able to advise you on the ideal dosage of CBD for your situation.
If you are a new user, we recommend starting your use with light doses at first. A few drops of oil under the tongue 3 times a week to start, then you can increase this dosage little by little, until you find your ideal dosage depending on the effects you are looking for.
Finally, it is highly recommended to consume quality products, purchased from trusted suppliers. Suppliers must deliver you the exact composition of the products, their source as well as their effects in the product sheet of the same. Poor quality products increase the risk of side effects or even create more for you.
If you experience persistent side effects from CBD, talk to your doctor.
Feel free to check out the ranges of CBD oil from boutique 321 CBD , a French boutique that offers premium CBD products at affordable prices, with free shipping with no minimum purchase amount.
The content of our website is for information purposes only. It is not intended to provide medical advice. We recommend that you seek the advice of a medical specialist before consuming any CBD product featured on our website.
CBD Oil for Gastritis – August 2022
Commonly prescribed medications and over-the-counter drugs for gastritis include omeprazole, rabeprazole, lansoprazole, dexlansoprazole, esomeprazole, and pantoprazole (6) . These drugs are some of the most potent inhibitors of stomach acid.
However, these medications may have side effects , such as iron and B12 deficiency, increased risk of fractures, pneumonia, and Clostridium difficile infections (7) . They can also be quite expensive over the long-term.
Clostridium difficile infections may cause diarrhea and eventually develop into a life-threatening medical condition .
Doctors may also prescribe antacids to treat gastritis by neutralizing stomach acid and providing pain relief. However, these drugs may result in constipation or diarrhea (8) .
A 2020 study in the International Journal of Molecular Sciences outlined CBD’s role in preventing and treating gastrointestinal disorders, like irritable bowel syndrome (IBS) and gastrointestinal cancer (9) .
The study demonstrated CBD’s anti-inflammatory properties in mice models of intestinal inflammation.
Gastritis is a collective term that refers to the inflammation of the lining of the stomach (10) .
Research in the Journal of Molecular Medicine evaluated CBD’s effects on an inflammatory bowel disease like ulcerative colitis (11) .
The authors found that CBD had anti-inflammatory properties beneficial for the inflamed gut. They also reported that CBD, a “likely safe compound,” prevented experimental colitis in mice.
Despite CBD’s purported health benefits on the digestive tract , it is essential to note the side effects of CBD use. These effects include diarrhea, changes in appetite or weight, and tiredness (12) .
CBD for Inflammation
A 2019 review archived in the journal Antioxidants stated that CBD had anti-inflammatory and antioxidant properties (13) .
The authors also mentioned CBD’s promise in treating disorders associated with inflammation and oxidative stress, such as cancer, cardiovascular, metabolic, and neurodegenerative diseases.
Another study documented in the journal Future Medicinal Chemistry discussed CBD’s effects on non-obese and diabetes-prone female rodents (14) .
The researchers found that CBD had anti-inflammatory effects that could help prevent type 1 diabetes.
CBD for Nausea
Common symptoms of gastritis include nausea and vomiting (15) .
Preclinical research showed that CBD might be useful in treating vomiting and nausea caused by chemotherapy and other treatments (16) .
A study archived in the British Journal of Clinical Pharmacology evaluated the effects of a dose containing CBD and tetrahydrocannabinol (THC) on patients with chemotherapy-induced nausea and vomiting (17) .
The researchers found that CBD and THC were well-tolerated and had antiemetic (vomit-preventing) properties.
They also observed that patients who received the cannabis-based medicine had better protection against delayed chemotherapy-induced nausea and vomiting.
CBD and THC are derived from the Cannabis sativa plant. However, unlike CBD, THC may get individuals high because of its psychoactive properties.
THC mainly comes from marijuana, a variant of the cannabis plant. Despite THC’s suggested benefits, medical marijuana use is not legal in the entire United States (18) .
CBD for Ulcers
Untreated gastritis may result in stomach ulcers and bleeding or stomach perforation (19) .
A 2018 study in the journal Phytotherapy Research evaluated CBD’s effects on oral wound healing (20) .
Standardized ulcers were induced in 60 rats. They were injected with 0mg (control), 5mg, and 10mg of CBD per kilogram of each rat’s body weight daily.
The researchers discovered that CBD had anti-inflammatory effects on the early phase of wound healing. However, they noted that their findings were insufficient to conclude that CBD use could improve oral traumatic lesions.
CBD as a Painkiller Substitute
The regular use of painkillers and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, may result in gastritis and ulcers (21) .
Meanwhile, s tudies showed that CBD products might have analgesic effects. Hence, they may be used as substitutes for painkillers.
A study published in the journal Postgraduate Medicine revealed that CBD improved chronic pain in participants using opioids for pain management (22) .
One hundred thirty-one patients were included in the study. The researchers found that half of the study sample was able to reduce opioid use eight weeks after adding CBD to their medication regimen.
Participants who used CBD reported improvements in their quality of life. Their chronic pain and sleep quality also improved.
In another research, results indicated that CBD had analgesic and anxiolytic (anxiety-reducing) effects (23) .
Three hundred ninety-seven individuals were prescribed CBD. Participants who had non-cancer pain reported improvements in their pain.
Meanwhile, those who had mental health symptoms experienced alleviation of their depression and anxiety symptoms.
CBD was well-tolerated, and the participants did not report any adverse effects. Other CBD benefits include improved sleep and appetite.
How CBD Oil Works to Alleviate Symptoms of Gastritis
A study documented in the PLOS One Journal evaluated how CBD purportedly reduces intestinal inflammation (24) .
Eighteen participants were included in the study. The results revealed that CBD might interfere with enteroglial-mediated interactions in an intestinal inflammatory environment.
Enteric glial cells make up the enteric nervous system, a regulatory system responsible for gastrointestinal function (25) .
According to the study, CBD was involved in the downregulation of the protein S100B, resulting in reduced intestinal damage during acute and intestinal inflammation.
S100 proteins have a vital role in mediating innate and acquired immune response s (26) . These responses significantly contribute to the development of chronic inflammatory diseases.
It is believed that CBD’s interaction with the endocannabinoid system (ECS) may be related to its anti-inflammatory properties.
The ECS has an essential role in maintaining the body’s natural harmony. To fulfill this function, it interacts with several organs and systems in the body, such as the endocrine and immune systems (27) .
A study conducted in 2019 outlined the role of CBD and the ECS’ cannabinoid receptors in inflammation (28) .
Research found that CBD was a weak agonist of the cannabinoid receptor 1 ( CB1 receptor ) in humans and mice. It also stated that CBD demonstrated inverse agonism of the cannabinoid receptor 2 (CB2 receptor) .
An agonist is a substance that mimics another substance’s action, stimulating an action (29) .
The researchers found that the activation of cannabinoid receptor 2 reduces oxidative stress and inflammation.
They also found that CBD’s anti-inflammatory activity involved the reduction of cytokine levels, the inhibition of T-cell proliferation, the induction of T-cell apoptosis, and the migration of immune cells.
Cytokines are molecules that direct cell movement to sites of inflammation, trauma, and infection (30) .
T cells contribute to sustained inflammation by producing proinflammatory cytokines (31) .
Apoptosis is programmed cell death vital in removing unnecessary or abnormal cells (32) .
The Pros and Cons of CBD Oil for Gastritis
- Previous studies showed CBD’s positive effects on symptoms associated with gastritis and other conditions related to the digestive system .
- Compared with conventional drugs prescribed for gastritis, CBD’s safety profile is more favorable (33) .
- There are no reported cases of human or animal dependence on CBD (34) . Hence, individuals considering using CBD to treat their gastritis should not worry about developing a dependence on the substance.
- Researchers should further investigate CBD’s effects on gastritis.
- Despite the benefits of CBD , it still has side effects, such as diarrhea, tiredness, and changes in weight or appetite (35) .
- Policies from the United States Food and Drug Administration (US FDA ) do not support CBD as therapy for medical conditions other than epilepsy.
How CBD Oil Compares to Alternative Treatments for Gastritis
A study archived in the Sultan Qaboos University Medical Journal investigated honey’s antibacterial effects on the bacterium Helicobacter pylori ( H. pylori) , the common cause of several digestive issues, such as gastritis and a very common contributor to the development of gastric and duodenal ulcers (36) .
The researchers concluded that some honey brands had antibacterial properties useful in treating H. pylori infections.
They also noted that when honey was used with antibiotics, such as clarithromycin and amoxicillin, there was no synergy or antagonism.
They recommend that honey may be useful as an adjunct therapy. It helps reduce the elimination time of H. pylori bacteria from the stomach lining of individuals with gastritis or duodenal ulcer.
Similarly, CBD was found to have antibacterial properties. Research in 2019 reported CBD’s efficacy in killing a range of Gram-positive bacteria (37) .
The researchers suggested that, given CBD’s anti-inflammatory properties and proven safety in humans, the substance held promise as a new antibiotic.
They also noted how CBD retained its efficacy against bacteria that became highly resistant to other traditional antibiotics.
Gram-positive bacteria are called such because they give a positive result when put under the Gram stain test (38) .
How to Choose the Right CBD for Gastritis
A previously cited study showed the efficacy of THC or medical cannabis on gastritis symptoms, such as vomiting and nausea. However, as mentioned earlier, THC use is not legal in all US states.
Full-spectrum CBD oil contains all the Cannabis sativa plant components, including terpenes, flavonoids, fatty acids, essential oils, and trace amounts of THC.
It is suggested that full-spectrum oils provide full therapeutic benefits because of the synergy of all the active ingredients of the cannabis plant. This mechanism is called the entourage effect.
The THC content of full-spectrum CBD products (less than 0.30%) is allowed by federal laws. However, this minimal amount may still be detected by drug tests.
Individuals who want to purchase CBD products free of THC may buy broad-spectrum CBD. This type of CBD oil has all the ingredients of the full-spectrum oil except for THC.
For pure, isolated cannabidiol, CBD isolates may be purchased.
Full-spectrum CBD oils are recommended for gastritis treatment. Still, individuals are encouraged to speak to a medical professional before purchasing any CBD product.
It is also essential to research if a manufacturer or dispensary is credible and authorized by the government to sell CBD to avoid buying illegitimate products.
CBD Dosage for Gastritis
Currently, no standard dosage chart has been developed for CBD in treating gastritis. However, it is recommended to begin with a small amount of CBD .
If no adverse effects are seen, the dosage may be increased gradually until the desired effect is achieved.
Individuals using CBD for gastritis are encouraged to keep a journal of their reactions to the substance. They may refer to this journal during consultations with their physician.
Before adding CBD to one’s gastritis medication regimen, it is recommended to inform a medical professional first.
How to Take CBD for Gastritis
There are several options when taking CBD for gastritis.
Some formats, such as CBD oils and tinctures (drops), allow individuals to take CBD directly. Tinctures may be applied sublingually, or under the tongue, for added efficacy.
CBD oils may be mixed with food or beverages to mask CBD’s naturally grassy taste.
CBD pills, gelcaps, capsules, edibles, and gummies may be ingested. This format also allows people with gastritis to conveniently bring their CBD medication with them anywhere.
This format is also appropriate for people with gastritis problems who want to take a consistent dosage of CBD.
CBD topicals, such as balms, salves, lotions, and ointments, may also be used. During episodes of abdominal pain or upset stomach , these topicals may be massaged into the affected area.
Some topicals contain soothing ingredients, such as peppermint and menthol, for added pain relief.
For instantaneous effects, CBD may be inhaled via vape pens. However, vaping CBD may be challenging, as it is hard to determine how much CBD was already taken.
In some individuals, vaping may also cause lung problems (39) .
According to Johns Hopkins Medicine, gastritis occurs when the stomach lining gets swollen (40) .
Gastritis may be caused by drinking excessive amounts of alcohol, eating spicy food , extreme stress, smoking, and long-term use of pain and fever medications.
Bacterial infections , major surgeries, and traumatic injuries or burns may also cause gastritis.
Gastritis may be classified as acute gastritis or chronic gastritis . Gastritis symptoms include the following (41) :
- Stomach upset or pain
- Belching and hiccups
- Bloating or gas
- Bleeding of the belly or abdomen
- Loss of appetite
- Nausea and vomiting
- Blood in the vomit or stool
- Weight loss
When untreated, gastritis may also result in other more severe health complications. These conditions include peptic ulcer disease (painful sores in the upper digestive tract) and tumors that could lead to stomach cancer .
A study also found that gastritis was associated with an increased prevalence of panic attacks, social phobia, major depression, and mood disorders (42) .
Previously mentioned studies found that CBD might be useful in treating gastritis symptoms, such as inflammation, nausea, and pain.
Compared with conventional medications prescribed for gastritis, CBD is generally safe because of its minimal side effects.
Like honey, CBD was found to have antibacterial properties.
CBD also comes in different forms and formulations, giving individuals with gastritis several options.
While CBD has been deemed for its favorable safety profile, in some individuals, CBD oil may be hard on the stomach.
For a more efficient treatment, it is best to consult with a healthcare provider before taking any CBD product for gastritis.