CBD And Fish Oil


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CBD oil is one of the most talked about health supplements in the last few years. Discover its surprising relationship to omega-3 fatty acids! New research suggests that omega-3 fatty acids can enhance endocannabinoid synthesis.

Does CBD Oil Need Omega-3 to Work?

Every day, there seems to be a new article about the growing popularity of CBD oil. Some articles speculate on the enormous economic growth that is expected from CBD products over the next few years, while others focus on CBD’s potential for reducing chronic pain and alleviating anxiety. The third type of article comes from researchers who cite discrepancies between users’ glowing accounts and clinical testing that does not support these anecdotes.

So is CBD oil a massive hype or a science-based gift from nature? And if it happens to be the latter, what’s the best way to maximize its effects?

What Is CBD and What Does It Do?

CBD (short for cannabidiol) is a substance extracted from the flower and leaves of the hemp plant. Discovered in the 1940s, CBD is one of over 100 identified cannabinoids in the Cannabis plant, accounting for up to 40% of the plant’s extract. Unlike another prevalent cannabinoid (THC), CBD does not appear to create the psychoactive effects associated with marijuana (1, 2).

The bulk of the research on CBD has focused on its ability to affect cell metabolism through what is called the endocannabinoid system. This system is involved in a wide range of physiological functions, including the regulation of our mood, inflammation response, immune system, and metabolism.

The precise mechanisms of how CBD works are not entirely clear; however, the main hypothesis is that CBD has a significant influence on the endocannabinoid system by mimicking the body’s own endocannabinoids.

What Are Endocannabinoids?

Found in every organ and tissue of the body, endocannabinoids are important lipids made naturally from the cells’ content of omega-3s and omega-6s. These lipids stimulate specialized cell membrane receptors, which in turn prompt the cell to perform specific tasks.

For instance, when certain types of endocannabinoids activate the endocannabinoid receptor CB1, the cell increases energy storage. Similarly, when endocannabinoids activate another receptor (CB2), they help to reduce pro-inflammatory cytokines (3). Note: These are the same receptors that cannabinoids (like CBD) act on, too.

THC, CBD, and CBN are three cannabinoids found in Cannabis. Mimicking the body’s endocannabinoids, they “unlock” the receptors CB1 and CB2, creating a variety of effects.

There are numerous types of endocannabinoids and endocannabinoid receptors, all of which have multiple impacts on the cells. Therefore, it can be incredibly difficult to generalize about their effects. However, this multi-purpose functionality helps to explain why the endocannabinoid system is believed to have an influence on many different diseases and health conditions.

How Are Omega-3s Connected to the Endocannabinoid System?

As mentioned above, endocannabinoids are lipids made from the cells’ omega-3 and omega-6 content. Once cells build up a sufficient inventory of these fatty acids, endocannabinoids are created rapidly and as-needed in response to brain activity and stimuli (like stress and exercise).

Omega-3s are directly involved in the synthesis of endocannabinoids, and also react with existing endocannabinoids to create omega-3-derived endocannabinoid epoxides (which have powerful anti-inflammatory properties)(4). Due to the important role that omega-3s have in the cell membrane, researchers believe that omega-3s also serve as crucial anchors for endocannabinoid cell membrane receptors (5).

To put it simply, omega-3s and endocannabinoids are totally dependent on each other in a healthy brain and body. This connection can also help explain why the noted anxiety and pain relieving effects from taking CBD oil are similar to the results achieved from receiving adequate omega-3 supplementation over time (6).

What Happens When You Don’t Get Enough Omega-3s?

Omega-3 deficiency is widespread in today’s world, impacting some 95% of adults in the United States (7). As researchers have demonstrated, this deficiency has serious consequences for the healthy functioning of our endocannabinoid systems.

Omega-3-deficient diets don’t just limit the creation of beneficial endocannabinoids and the omega-3-derived endocannabinoid epoxides. Studies have also shown that omega-3-deficiency creates dysfunctional endocannabinoid receptors, uncoupling them from the protein and altering signaling pathways in the brain (8).

Health Consequences of Omega-3 Deficiency

Consequences of dysfunctional endocannabinoid receptors (due to omega-3 deficiency) include increased anxiety and impaired behavior, according to one mice study from the University of Bordeaux (9). In addition, studies also show that omega-3 deficiency plays a role in increasing the development of obesity through the dysregulation of the endocannabinoid system (10).

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Chronic deficiency of omega-3s in our diet may partly explain society’s enormous craving for CBD products. What’s more, it may also help to explain the widely-diverse experiences that CBD users have. After all, if one person’s endocannabinoid receptors are dysfunctional, throwing lots of cannabinoids at them won’t necessarily produce the results users are hoping to achieve.

While more research is needed to address these important topics, the above studies raise pressing questions.

Most people in the United States do not get enough omega-3s, either from diet or supplements. This is in stark contrast with other countries, like Japan, where omega-3 intakes are much higher.

Why Do People Prefer CBD to Omega-3 Supplements?

Considering the deep involvement of omega-3s in the endocannabinoid system, you would think that anyone fascinated by CBD’s effects would also have a dual interest in fish oil. However, when compared to most omega-3 supplements, CBD has clear advantages.

While CBD’s effects appear quickly, omega-3s take longer to work – often many weeks of consistent consumption. These rapid effects probably explain why CBD is creating such a buzz. With CBD products, people are also willing to take an adequate dose, but that often isn’t the case with omega-3 products.

CBD, however, does not solve the underlying omega-3 deficiency problem.

Many people have asked us if we make any products with CBD oil in them, but as of the time of publication, we do not. Please also note that the FDA has made it clear that combining CBD into existing supplements is currently not allowed.

Is CBD a Panacea?

Some years ago, I attended a meeting on the effects of a new molecule that had potential for treating Alzheimer’s. The presentation was inspiring, and left attendees with a feeling that this new molecule could be a major therapeutic tool.

Afterwards, I had the chance to discuss the science with the presenter one-on-one.

“Do you believe that a single molecule will do the whole trick in curing or preventing this disease,” I asked.

“Of course not,” he answered. “But the investors may believe it.”

Most physiologists and biologists know that single molecules are rarely a cure-all for complex health issues. Unfortunately, this point often gets missed when we get too focused on isolated substances — either because of the pharmaceutical industry’s desire for patentable products or the appeal of easily understandable buzzwords. The human body and cell metabolism are extremely complex and dependent upon the interactions of a multitude of factors (e.g. genes, environment, nutrition, microbiome, age, gender, etc). Therefore, it’s highly unlikely that changing just one factor will solve chronic conditions for most people.

There isn’t a single substance – whether that’s CBD or even omega-3s – that will ever give us a one-way ticket to good health. But when we understand the underlying mechanisms of the body and employ a synergy of wholesome efforts, we’ll be able to carve a better path forward.

This is the philosophy that guides us at Omega3 Innovations. It’s the reason we’ve created a full-spectrum oil, and the reason we’re passionate about the combination of our Omega Cure oil with melatonin and vitamin D3. It’s why we care about not just increasing our consumption of omega-3s, but also decreasing our intake of omega-6s, and why we like to share advice about how to improve sleep hygiene.

Combination therapy, in our book, is where the biggest medical innovation will come from in the future, and we’re excited to be exploring these principles as a company.

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CBD And Fish Oil

Chances are, you’ve probably heard about CBD, and how the many molecules it contains (cannabinoids) can benefit health and wellness. In fact, according to the most recent national poll, 1 in 7 of you reading this article are already using phytocannabinoids (cannabinoids derived from plants) for their various physiological effects and functions. 1

But do you understand how cannabinoids “work” within the body? And did you know that simple adjustments to your diet can promote your body’s natural production of molecules called endocannabinoids? Read on to discover how you can support your endocannabinoid system with or without external sources of cannabinoids.

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The Endocannabinoid System: Nature’s Balancing Act

Over the past thirty years, studies exploring the physiological effects of cannabis have led to the discovery of a complex cell signaling network called the endocannabinoid system. 2 – 4 This is a network of lipid (fat)-based signaling molecules called endocannabinoids and the cells that detect them. Importantly, the endocannabinoid system plays an integral role in maintaining balance throughout the body—a vital process called homeostasis. 5

Homeostasis is the ability to maintain a relatively stable internal state despite changes in the external environment. Common examples of homeostatic processes include regulation of body temperature, blood sugar, and blood pressure.

Essentially, whenever an internal function becomes irregular due to injury, insult or illness, a well-functioning endocannabinoid system will respond by synthesizing chemical messengers called endocannabinoids in the brain, organs, connective tissue, glands, and immune cells. 5 These endocannabinoids will then bind with cannabinoid receptors in the central nervous system and immune system to set into motion a variety of cellular responses aimed at restoring balance to the irregular function. 5

Cannabinoid Receptors and Functions

To date, two primary cannabinoid receptors have been identified: CB1 and CB2. Whereas CB1 receptors are found primarily on the surface of cells in the brain and spinal cord, CB2 receptors are largely found on cells in the immune system. 6 Importantly, because these receptors are widely distributed throughout the body, the endocannabinoid system can help regulate the body’s:

  • inflammatory response, 7
  • perception of pain, 8
  • reproductive function, 9
  • sleep/wake cycle, 10
  • stress response, 11
  • mood and anxiety, 12
  • immune system, 13 and more. 14

Types of Cannabinoids: Endocannabinoids and Phytocannabinoids

The human body produces a variety of endocannabinoids, some of which are derived from omega-6s, and some of which are derived from omega-3s. The two most well-researched endocannabinoids are anandamide and 2-AG, which come from the omega-6 fatty acid, arachidonic acid. Unlike endocannabinoids, which are synthesized within the body (endo- meaning “within”), THC and CBD are phytocannibinoids—a type of cannabinoid derived from plants (phyto- meaning “relating to plants”). 15 Although there are more than 85 different types of phytocannabinoids known to date, CBD and THC are by far the most well-known and well-researched. 16

THC is considered the mimetic phytocannabinoid of the endocannabinoid anandamide, and similar to anandamide, binds directly to CB1 receptors. 17 Along a similar vein, CBD is considered the mimetic phytocannabinoid of the endocannabinoid 2-AG, and like 2-AG, interacts with both CB1 and CB2 receptors. However, unlike 2-AG, anandamide, and THC—which bind directly to cannabinoid receptors—CBD affects cannabinoid receptors indirectly. 17

Cannabinoids Promote Homeostasis by Influencing Neuronal Communication

The most well-researched homeostatic process that the endocannabinoid system regulates is the speed of communication between cells of the nervous system called neurons. Similar to other neurotransmitters such as dopamine and serotonin, cannabinoids “talk” to neurons in the brain through the release of chemicals. 6

The communication actually occurs when one neuron sends a chemical messenger, or neurotransmitter, to another neuron across a gap called the synapse. Every time a neurotransmitter is sent, this is called neuron firing or transmission. The rate of neuron firing determines the speed that the brain and body can react to various stimuli, but too little or too much firing prevents us from functioning normally. 18 In essence, the endocannabinoid system helps maintain the balance of neuronal transmission by slowing down the rate of neuron firing. Now here comes the really interesting part.

Whereas in most neurotransmitter systems, the sending neuron (pre-synaptic neuron) releases excitatory or inhibitory chemicals across the synapse to the receiving neuron (post-synaptic neuron), in order to slow down neuronal transmission, endocannabinoids are sent in the reverse order—from post-synaptic neuron to pre-synaptic neuron. 6 Then, when endocannabinoids bind to receptors on the pre-synaptic neuron, they inhibit the firing of that neuron. 18 In effect, the endocannabinoid system promotes homeostasis by putting the brakes on neuronal speed by limiting the release of neurotransmitters.

Role of Omega-3 and Omega-6 fats in Endocannabinoid Synthesis and Function

Consuming EPA and DHA can provide many of the same benefits as cannabinoids

Intriguingly, the past fifty years of research on omega-3 fatty acids suggest that consuming an adequate amount of EPA and DHA can provide many of the same benefits as cannabinoids. 19 In truth, this really isn’t that surprising, given that endocannabinoids are lipid-based signaling molecules that are synthesized internally from omega-6 and omega-3 fatty acids. What’s more, research shows that the effects of endocannabinoids can be significantly influenced by the type of fatty acids consumed. 20 , 21 More specifically, their effects can be influenced by the ratios of omega-3 and omega-6 fatty acids consumed.

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For example, new research suggests that the consumption of omega-3 fatty acids actually shifts the balance of endocannabinoids towards a higher proportion of omega-3 endocannabinoids (e.g., DHEA, EPEA) as well as endocannabinoid-like molecules that form when omega-3s combine with neurotransmitters like dopamine and serotonin (e.g., DHA-serotonin, EPA-dopamine). 20 Importantly, these omega-3 endocannabinoid and endocannabinoid-like molecules are believed to control vital physiological processes in the body—such as the body’s inflammatory response, pain, and more. 20 , 21

Research also suggests that a diet high in omega-3s can positively influence the neurological functions of the endocannabinoid system. In a study looking at the links between diet, brain functioning, and the endocannabinoid system, researchers fed mice a diet modeled after the Standard American diet—one high in omega-6 fatty acids, and low in omega-3s. Importantly, the omega-3-deficient mice displayed altered brain function and cannabinoid receptor activity in brain areas related to emotional behavior and mood disorders. 22 Put more simply, mice that were deprived of omega-3 fatty acids showed reduced cannabinoid receptor activity and increased depressive behaviors, while these effects were not observed in the mice fed a balanced diet rich in omega-3s.

In light of the reduced endocannabinoid binding and neurological functioning observed in the omega-3-deficient mice, these results suggest that a western diet may have serious implications for neurological health and overall well-being. 22 The good news, however, is that eating a diet with approximately equal ratios of omega-6 and omega-3 fatty acids can help preserve a healthy endocannabinoid system.

Promote Your Health Naturally

Regardless of how you feel about taking external cannabinoids, it is difficult to dispute the benefits of the endocannabinoid system, and its unique ability to restore homeostasis when physiological functions go awry. The fact that research suggests a diet low in omega-3s can disturb cannabinoid function and synthesis, while a diet rich in omega-3 fatty acids can help promote the synthesis of omega-3 endocannabinoids, suggests that simple changes to your diet and/or the addition of omega-3 fish or algae oil can greatly (and naturally!) enhance your health.

Gina Jaeger, PhD is a Developmental Specialist and Lead Research Writer for Nordic Naturals. She holds a doctorate in Human Development, and has published several research articles on children’s cognitive development. Gina enjoys studying and educating others on strategies for optimizing health and wellness throughout the lifespan.

Anandamide and 2-AG: The main two endocannabinoids and are synthesized from omega-6 and omega-3 fatty acids.

Cannabinoids: Molecules derived from fatty acids that binds to cannabinoid receptors.

Cannabis: Any plant of the Cannabis species; does not indicate the presence or absence of the hallucinogenic phytocannabinoid THC.

CB1 and CB2: The two main receptors of the endocannabinoid system, and widely distributed throughout the body. CB1 receptors are primarily found on the surface of cells in the brain and spinal cord, while CB2 receptors are largely found on cells in the immune system.

CBD: Cannabidiol, a phytocannibinoid that acts indirectly on cannabinoid receptors to help restore homeostasis.

Cannabinoid receptors: Cell membrane receptors involved in a variety of physiological processes.

Endocannabinoid System (ECS): Consists of cannabinoid receptors, endocannabinoids, and the metabolic enzymes that synthesize and break endocannabinoids down.

Endocannabinoids: Chemical messengers synthesized by the endocannabinoid system to restore physiological functions.

Homeostasis: Any self-regulating process by which biological systems tend to maintain stability; state of steady internal physical and chemical conditions while adjusting to conditions that are optimal for survival.

Phytocannabinoids: Cannabinoids derived from plants; the most prevalent types are CBD (cannabidiol) and THC (tetrahydrocannabinol).

Pre-synaptic neuron: A nerve cell that sends a chemical messenger, or neurotransmitter, across the synapse.

Post-synaptic neuron: A nerve cell that receives a chemical messenger, or neurotransmitter, after it has crossed the synapse.

Synapse: The site of transmission between a neuron sending a chemical or electric signal to the neuron receiving it.

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