CBD Oil And Ativan

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I have clusters of seizures that take hours to break (100-150 seizures) and i take 2-3 milligrams of Ativan to break the cluster. Anyone kno There is no known drug interaction between CBD (cannabidiol) and Ativan (lorazepam). However, both can cause sedation and drowsiness.

CBD Vs Ativan

I have clusters of seizures that take hours to break (100-150 seizures) and i take 2-3 milligrams of Ativan to break the cluster. Anyone know if CBD would benefit me.

I use Ativan and CBD oil, it doesn’t seem to bother me at all. In my case, I definitely need both, especially if stressed or tired.

In your case don’t get rid of your Ativan by any means but it would not hurt to see what the CBD would do for you! Look into third party tested CBD. Make sure it doesn’t have any strange additives. Some companies got caught putting cough syrup and other junk in their CBD.

@A MyEpilepsyTeam Member i took almost every med possible with no help. some of the meds made me have clusters of seizures. the only thing that works is a keto diet (lesson the seizures) and the cbd oil. just go with your gut feeling and do a little research.

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Yes i take very high doses of my medicantions but i deal with cluster seizures and Ativan is my go to. But if there was something out there that could take them away faster than 2+ hours i would love it. Im currently on 2400mg of Carbamazipine , 800mg of Topiramate and up 5mg of Ativan which i never need that much

i used to have seizures once every hour. i had surgery and it lesson from every hour to a couple times a day. about a year ago i used koi 500mg cbd oil and my seizures are gone. i take meds but it is small.
i swear by this stuff. be careful, there is a lot of knock off cbd oil.

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CBD (Cannabidiol) With Ativan (Lorazepam) Interaction

No known interactions but watch out for potential sedation.

Baba asked

I have been taking 0.5mg of Ativan (lorazepam) mid-day and at night for about 6 years to help me with anxiety due to shortness of breath. Can I try CBD oil twice a day with this? I would like to wean off lorazepam if hemp oil helps with this and insomnia.

At a glance

  • There is no known drug interaction between CBD (cannabidiol) and Ativan (lorazepam).
  • However, both can cause sedation, drowsiness and dizziness so caution must be taken when combining them.

Answer

There are no known interactions between Ativan (lorazepam) and CBD (cannabidiol). However, both can increase sedation and somnolence (feeling of sleepiness).

Therefore, caution is advised when using both together and you should not operate heavy machinery or take part in activities that require mental alertness until you know how both medications affect you.

Below, I discuss CBD, Ativan and potential interactions in more detail.

What Is CBD (Cannabidiol)?

Cannabidiol, often referred to simply as ‘CBD’, is one of the many constituents of marijuana and is known to be an active component in regard to activity with our endocannabinoid system.

Unlike THC (delta-9-tetrahydrocannabinol), CBD is thought to be ‘non-psychoactive’ in that it doesn’t cause a ‘high’ or euphoria. Nevertheless, it certainly does affect the central nervous system as studies show it can be beneficial for symptoms of anxiety and can cause sedation.

CBD has been investigated for a wide variety of therapeutic effects, including:

  • Chronic Pain
  • PTSD
  • Multiple sclerosis
  • Parkinson’s Disease
  • Epilepsy
  • Huntington’s Disease

In addition, CBD may make high THC preparations more tolerable for individuals as it can ‘attenuate’ or reduce the ‘high’ experienced without reducing potential medicinal effects.

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CBD Side Effects

CBD is very well tolerated in most individuals and is not associated with dependence or withdrawal symptoms, even after extended use.

Although CBD can cause sedation and a general feeling of tiredness, it is not associated with respiratory depression and has been used safely with CNS depressants such as opioids and benzodiazepines. Nevertheless, CBD can cause additive drowsiness when used with other medications with similar side effects (e.g. lorazepam).

The overall side effect profile of CBD is minimal, especially at doses that are used in over the counter products (~3-15 mg) per dose.

Even high doses of CBD are considered well-tolerated. The prescription product Epidiolex, which comes in a concentration of 100 mg/ml and is used for rare seizure disorders, provides a high amount of CBD and lists the following side effects in the prescribing information for the drug:

  • Decreased appetite (16-22% incidence)
  • Diarrhea (9-20% incidence)
  • Sedation (3-6% incidence)
  • Lethargy (4-8% incidence)
  • Somnolence (23-25% incidence)
  • Sleep disturbances (5-11% incidence)

CBD Drug Interactions

There is a lack of information regarding interactions with CBD products and it appears that some may be dose-related (meaning higher doses increase the risk of interaction) (14). Potential interactions stem from the fact that CBD may inhibit certain CYP metabolizing enzymes in the liver, including:

When a metabolizing enzyme is inhibited, it cannot break down a drug as effectively or as quickly, leading to increased concentrations. This can increase the risk of side effects.

A good example of this is the interaction between Lipitor, a cholesterol-lowering medication, and clarithromycin, an antibiotic. Clarithromycin can inhibit CYP 3A4, which is responsible for metabolizing Lipitor. This increases concentrations of the drug, putting individuals at risk for serious side effects, such as rhabdomyolysis.

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It should be noted that most interaction studies with CBD have been only done in animals and the extent of potential interactions in humans isn’t well known.

Ativan (lorazepam), the drug in question regarding CBD interactions, is not metabolized by CYP enzymes, but rather by liver glucuronidation. As far as we know, CBD has no effect of Ativan concentrations in the body.

Lastly, the concern with combining CNS depressants together is the risk of respiratory depression. Opioids and benzodiazepines are well associated with it. CBD products, however, are not and are generally considered safe in that regard.

Ativan Information

Ativan (lorazepam) is a rapid-acting benzodiazepine medication and is used primarily for the treatment of anxiety disorders.

It has several advantages over other benzodiazepines, including:

  • It is not metabolized by CYP liver enzymes and has fewer potential drug interactions when compared to medications that are.
  • It does not have active metabolites and therefore doesn’t accumulate in the body. This can be beneficial in certain populations, such as the elderly.

The most common side effects of benzodiazepines, like Ativan, are as follows:

  • Sedation
  • Fatigue
  • Memory impairment
  • Dizziness
  • Impaired motor coordination
  • Shallow breathing (high doses)

Taking CBD With Ativan

As discussed, there are no known interactions between CBD and Ativan. However, it is important to know that both can cause sedation and a general feeling of fatigue, which could be additive if taken together.

It is important to let your doctor know all the medications/over the counter products you are taking so you can be appropriately monitored.

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