CBD Oil Cause Hives

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CBD is known to have very few side effects, but can it cause itching? We take a look at whether CBD can cause allergies and itchy skin. Studies are showing that CBD can reduce itching — but can this symptom also be the result of an allergic reaction to CBD oil? Let’s explain why some people claim that CBD oil can cause itching.

Can CBD Oil Cause Itching? [Explained]

Most experts consider cannabidiol (CBD) to have an excellent safety profile and minimal risk of side effects. However, some patients have reported experiencing itching after using CBD oil. Could this be a CBD side effect or merely a coincidence?

In this article, we’ll answer the question, “can CBD oil cause itching?” Read on to learn more.

Does CBD Make You Itch?

One of the reasons CBD has become so popular is that it generally causes very few adverse effects.

A 2017 review for Cannabis and Cannabinoid Research investigated the safety and side effects of CBD. It concluded that CBD has a favorable side effect profile in comparison to many pharmaceuticals that treat the same conditions.

That said, side effects did occur, with the most common being tiredness, diarrhea, and appetite/weight changes. The report makes no mention of itching as a potential CBD oil side effect.

However, in the UK, the Medicines and Healthcare Products Regulatory Agency (MHRA) had different findings. The MHRA runs the Yellow Card Scheme, which provides consumers with an opportunity to report adverse reactions after using a specific medicine or supplement.

The 2019 report suggests that there were at least two cases of rashes and itching after using CBD oil. One patient took CBD orally and experienced urticaria, a severe skin reaction involving red welts, swelling, and intense itching. Another used CBD both orally and topically and also experienced itching.

It seems that the most likely explanation for these adverse effects is an allergic reaction to CBD oil. So, how common is this problem, and are there any other symptoms?

Exploring the advantages and d…

Itching and Other CBD Oil Allergic Reaction Symptoms

There is little information available on CBD oil allergies. However, there is some research into cannabis allergies in general. The Annals of Asthma, Allergies, and Immunology conducted a study in 2013. It concluded that there had been cases of hypersensitivity and even anaphylaxis after using marijuana.

Anaphylaxis, or anaphylactic shock, is an extreme allergic reaction. It results in swelling of the airways and an inability to breathe and can potentially be fatal. Other cannabis allergy symptoms include:

  • Sore throat
  • Rhinitis (nasal inflammation)
  • Nasal congestion
  • Wheezing
  • Shortness of breath
  • Watery eyes
  • Swelling

Furthermore, the report states that workers in hemp processing facilities may experience higher rates of respiratory problems. The authors point out that most cannabis allergies occur due to smoking and direct handling. However, consuming edibles could also potentially cause a reaction.

The AAAAI (American Academy of Allergy, Asthma, and Immunology) says that cannabis allergy can develop due to “inhaling, smoking, touching, and eating marijuana.” It states that touching the plant could cause rashes, hives, and swelling in sensitive individuals.

Since CBD comes from cannabis plants, it is reasonable to assume that those with cannabis allergies could also be sensitive to CBD. However, more research is necessary to confirm how many people are allergic to CBD oil and to what extent.

Can CBD Oil Cause a Skin Rash?

As we have already mentioned, there have been isolated reports of CBD causing a skin rash. This side effect may be more widely reported with a particular form of CBD known as Epidiolex.

Epidiolex is the only form of CBD with full approval from the Food and Drug Administration (FDA). Therefore, scientists have tested it rigorously for both potential benefits and side effects. The drug’s prescribing information lists rashes as one of the most common side effects of Epidiolex.

It also states that the drug could cause liver problems. One of the symptoms of this is itching. Other signs of liver issues include:

  • Reduced appetite
  • Nausea
  • Vomiting
  • Fever
  • Tiredness
  • Jaundice (yellowing of the skin and eyes)
  • Dark urine
  • Pain in the upper-right abdominal area

Anyone experiencing these side effects after taking Epidiolex or CBD oil should seek medical advice immediately.

Can CBD Oil Cause Itchy Eyes?

Itchy eyes are a common allergy symptom. Pollen allergies often cause the eyes to become red, watery, and itchy. Therefore, someone allergic to cannabis coming into contact with cannabis or hemp pollen could experience these effects.

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Those who use marijuana regularly may be familiar with the tell-tale side effect of red or bloodshot eyes. However, this is not due to CBD but the intoxicating compound in cannabis, THC.

Red eyes result from THC causing the blood vessels to relax and widen. Many believe that, for the same reason, marijuana could be a useful glaucoma treatment.

We couldn’t find any reliable reports of CBD oil causing itchy eyes, but that does not mean it is impossible. Let us know in the comments at the end of the article if you have experienced this.

CBD and Itching: The Problem or the Solution?

Although some people have experienced itching after using CBD oil, this reaction only affects a minority of users. In fact, some research suggests that CBD could offer a solution to itching in skin conditions such as psoriasis and dermatitis.

CBD impacts the body by interacting with the endocannabinoid system (ECS). This system is present in most of the body’s tissues, including the skin. Experts believe that it regulates the growth and development of skin cells and influences their immune function.

The ECS is also present in the skin’s nerve endings and plays a role in sensory perception, including pain and itching. These effects are under the control of numerous cell receptors, including cannabinoid receptors (CB1 and CB2). These receptors become active when they bind with chemicals called endocannabinoids that our bodies naturally produce.

It seems that CBD works primarily by increasing the levels of these endocannabinoids to enhance ECS function. This effect means that CBD could be more likely to relieve itching than cause it.

A 2006 study for the German journal Der Hautarzt tested a compound called N-palmitoyl ethanolamine (PEA) in 22 patients with itching due to various skin conditions. The chemical is a cannabinoid agonist, meaning that it stimulates receptors in the ECS. Of the 22 participants, 14 experienced reductions in itching, and the average reduction was an impressive 86.4%.

This study, unfortunately, had a very small sample size, and more research is necessary to confirm its results conclusively. However, these preliminary findings suggest that, unless you have a CBD allergy, the compound is more likely to act as a solution to itching than a cause.

Can CBD Oil Cause Itching? Final Thoughts

It seems that CBD oil may cause itching in a small number of consumers. This reaction is most likely the result of a CBD allergy or sensitivity to other ingredients in the product. The latter could be especially true when using topical CBD products, as these contain a variety of components that could potentially irritate the skin.

We advise anyone considering using CBD skin creams to look for a product containing all-natural ingredients and as few of them as possible. This precaution is especially important if you have sensitive skin or other allergies.

As always, we only recommend buying CBD from reputable brands that publish third-party lab reports on their websites. Products that have not undergone testing may contain contaminants and increase the risk of adverse reactions like itching.

And finally, if you do experience itching after taking CBD, we suggest that you stop using it immediately. Make an appointment with a physician who will be able to run tests and advise you further.

Can CBD Oil Cause Itching?

According to many experts and official reports from international health agencies, CBD has an excellent safety profile, with only a few benign side effects.

However, for some patients, CBD may cause reactions that aren’t experienced by other people — such as itching.

Is it a coincidence, or does CBD oil really cause itching?

In this article, we leave no doubt behind potential allergic reactions to CBD products — and how to avoid them.

Can CBD Cause Itching?

One of the main reasons CBD has become so popular is that it generally doesn’t have serious adverse effects. In a 2017 review published in the journal Cannabis and Cannabinoid Research, the authors concluded that CBD is safe and well-tolerated by humans in comparison to many pharmaceuticals that are prescribed for the same conditions ( 1 ).

That said, there are a few side effects that you might experience when taking large doses of CBD oil. The most common side effects of CBD include dry mouth, changes in appetite, dizziness, and — in extreme cases — diarrhea.

According to the report issued by the Medicines and Healthcare Products Regulatory Agency (MHRA), CBD might cause itching in some individuals. The MHRA is an agency that provides consumers with the opportunity to report adverse reactions after taking certain supplements.

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The report stated that there were at least two cases of itching after taking CBD oil. One person took CBD orally and experienced a severe skin reaction known as urticaria. Another used both oral and topical forms of CBD — and also experienced itching .

Whether these side effects were caused by CBD alone, some other compounds of hemp oil, or by impurities is unknown.

So, how common is itching after CBD oil, and does it have any other alarming symptoms?

Itching and Other Allergic Reactions to CBD Oil

The information on CBD oil and allergies is scarce. However, it seems that people can develop allergies to cannabis in general.

The Annals of Asthma, Allergies, and Immunology conducted a study in 2013, where they reported cases of hypersensitivity and even anaphylaxis after using marijuana ( 3 ).

Anaphylaxis, also known as anaphylactic shock, is a severe allergic reaction that causes the swelling of the airways and makes people unable to breathe. The reaction can even be fatal.

The symptoms of allergies to cannabis include:

  • Rhinitis (nasal inflammation)
  • Sore throat
  • Wheezing
  • Shortness of breath
  • Dry eyes
  • Swelling
  • Shortness of breath
  • Nasal congestion

Some studies also suggest that high doses of cannabis could result in asthma and bronchitis. However, the results are conflicted, as there are at least a few studies suggesting that cannabis can be used for the treatment of asthma — being part of the medical cannabis program in many states.

Again, we’d need to consider the purity of cannabis and its derivatives in the studies that indicated the risk of allergic reactions to the plant. Cannabis grown on illegal sites can be contaminated with pesticides, heavy metals, synthetic cannabinoids, and blends of drugs that are used to potentiate its psychoactive effects by black market vendors.

The authors of the study also found that workers in hemp processing facilities may have higher rates of respiratory disorders. They point that cannabis allergies occur due to inhaling and direct handling, although edibles could also potentially cause allergies.

Since CBD is derived from cannabis, it’s within reason to assume that people with cannabis allergies can also be sensitive to CBD.

More research is required to draw definitive conclusions, especially with the purity of cannabis products in mind.

Can CBD Oil Trigger a Skin Rash?

As mentioned earlier in this article, the reports of skin rashes and itching after CBD oil are few and far between — at least when it comes to hemp-derived CBD oil. This side effect might be more common with a synthetic form of CBD known as Epidiolex.

Epidiolex is the only form of CBD that has received full approval from the Food and Drug Administration (FDA). Therefore, researchers have investigated it in terms of both potential benefits and side effects.

The information on the drug’s prescription lists rashes as one of the most common side effects of Epidiolex.

It also notes that the drug can trigger liver problems. One of the symptoms of this reaction is itching.

Other signs of liver problems include:

  • Fever
  • Nausea
  • Vomiting
  • Pain in the upper-right abdominal area
  • Yellowing of the skin and eyes
  • Dark urine
  • Reduced appetite

It’s worth noting that the above reactions refer to synthetic forms of CBD. There have been no such issues with hemp-derived CBD oil that has been tested for potency and purity by an independent laboratory. So, when buying products online, make sure to check and read these lab test results to know the potency of the products you are going to purchase and their contents.

Anyone experiencing the above side effects after Epidiolex should seek medical attention immediately.

Can CBD Oil Make Your Eyes Itch?

Itchy eyes are an obvious indicator of allergies. Pollen allergies often make our eyes dry, red, watery, and itchy. In other words, if you’re allergic to hemp and get into contact with the plant’s pollen, this could trigger itchy eyes.

Marijuana users may be familiar with the tell-tale effect of red eyes after consumption. However, this side effect is not to be confused with the dryness caused by allergies. Dry and red eyes after consuming marijuana result from its effects on the blood capillaries surrounding the ocular nerves; when THC enters your system, the capillaries get dilated, resulting in increased blood flow — and giving you the ruby eyes.

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There are no reliable reports of itching caused by CBD oil. However, this doesn’t mean it’s impossible. Let us know in the comments if you have experienced itching after taking CBD products.

CBD and Itching: The Cause or the Solution?

Although some people have experienced itching after taking CBD products, it seems that this side effect only affects a very small percentage of users. In fact, some studies suggest that CBD could offer relief from itching in skin conditions such as psoriasis or eczema.

CBD works in the body by interacting with the endocannabinoid system (ECS). The ECS has cannabinoid receptors all over the body, including the central nervous system, peripheral nervous system, and all organs. The ECS has been found to regulate many essential biological processes — such as immune function.

When you take CBD oil for itching, it interacts with the CB2 cannabinoid receptors that modulate the activity of immune cells. CBD can both improve the communication between these cells — ensuring the healthy functioning of the immune system — and reduce inflammation by inhibiting the release of pro-inflammatory proteins called cytokines.

Lower inflammation markers have been associated with an anti-inflammatory response, including a reduction in pain, swelling, redness, and itching.

On top of that, CBD indirectly signals the ECS to release more of its endocannabinoids. It also slows down their breakdown by blocking the enzyme called Fatty Acid Amide Hydrolase (FAAH) Once released, they also bind to cannabinoid receptors, bolstering the immunomodulatory effects of cannabidiol.

In a 2006 German study published in the journal Der Hautarzt , the research team tested a compound called N-palmitoyl ethanolamine (PEA) on 22 patients with various skin conditions. The compound is a cannabinoid agonist, meaning it activates the receptors of the ECS ( 4 ).

Of the 22 participants, 14 experienced relief from itching, with an average reduction score of 86.4%.

Unfortunately, the study had a very small sample size; therefore, more large-scale studies are necessary to confirm these results with greater confidence.

Nevertheless, the preliminary findings are very promising, suggesting that CBD is more likely to solve the problem of itching rather than to cause it.

So… Can CBD Oil Cause Itching?

Although some individuals reported itching after using CBD oil, this adverse reaction might affect only a small percentage of users. Moreover, itching doesn’t have to be caused by CBD itself; instead, it may result from contamination with toxic compounds that can irritate the skin and trigger allergies.

The reaction can also be caused by other hemp compounds that are present in full-spectrum and broad-spectrum CBD oils. Natural ingredients are known to cause allergies in sensitive users, so if you suspect that CBD oil causes itching in your case, opt for isolate-based products, as they only contain CBD.

There are two things you can do to avoid experiencing itching after taking CBD oil. First, always make sure to buy CBD products from a reputable manufacturer that provides relevant and up-to-date lab reports for every batch. We also suggest that you consult a doctor and run allergy tests if you believe that you’re allergic to any of the ingredients found in whole plant extracts.

Have you ever experienced itching after taking CBD oil? Share your stories in the comment section!

References:

  1. Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research , 2 (1), 139–154. https://doi.org/10.1089/can.2016.0034
  2. Food.gov.uk. (2019) Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment. Available at: https://cot.food.gov.uk/sites/default/files/tox2019-32.pdf
  3. Nayak AP, Green BJ, Sussman G, et al. Characterization of Cannabis sativa allergens. Ann Allergy Asthma Immunol . 2013;111(1):32-37. doi:10.1016/j.anai.2013.04.018
  4. Ständer, S., Reinhardt, H. W., & Luger, T. A. (2006). Topische Cannabinoidagonisten. Eine effektive, neue Möglichkeit zur Behandlung von chronischem Pruritus [Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 57(9), 801–807. https://doi.org/10.1007/s00105-006-1180-1
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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