CBD Oil Side Effects On Liver

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The liver is involved in a wide range of critical physiological functions. This article explores the ways CBD can affect our liver. CBD restores liver function according to some studies, but one study has found extreme doses to actually hurt the liver. What’s the truth about CBD oil and liver health? How does the liver respond to regular amounts of CBD? <span><b>Introduction:</b> Previous studies have suggested that prescribed cannabidiol (CBD) products may cause elevations in liver tests (LT). This study compared the prevalence of elevated LT in an adult population self-administering CBD with the normal and general adult population prevalences. <b>Mater</b></span> …

CBD & Liver Damage: Learn If CBD Can Actually Affect Liver Functions!

Studies show a higher prevalence of liver cirrhosis or liver damage in the United States of America than before. It is an important health concern and a significant reason for morbidity and mortality.

Due to the prevalence of liver damage, the use of CBD oil has grown in popularity across the United States. The public has become more aware of the health benefits and the possible adverse effects of CBD usage.

Can CBD Cause Liver Damage?

CBD oil has a low risk of side effects, thus. Researchers used daily doses of 1,500 mg to 3,000 mg CBD to examine the safety and effectiveness of CBD in humans. A sample group took a dose of 1,500 mg of CBD for six weeks; scientists identified no life-threatening negative effects.

Recent research on mice in 2019 found that increased dosages of CBD can harm the liver, garnering significant media coverage. The study also caught the attention of people who have been seeking a major side effect to disprove CBD’s therapeutic potential. Like every other medicine, CBD does have its side effects, but the real question is if it is harmful to liver function when taken in an average dose.

  • Effect Of CBD On The Liver Of Mice

The University of Arkansas conducted research on a group of 8-week-old mice to study the treatment of various dosages of CBD. The research had a problem: there were not enough extensive toxicological studies on CBD safety. It was crucial to establish the effects since companies continue to market CBD and CBD-derived goods.

Likewise, when scientists give mice repeated doses of a lower concentration of CBD (50 mg), it results in liver damage and edema. Due to the difference in the physiology of humans and mice, the size of the liver is one of the many aspects that they must consider. When analyzing the benefits of CBD in human beings, it is vital to know how far these differences fare.

According to previous studies, CBD products, when prescribed to adults, resulted in elevated liver tests. Hence, scientists conducted a study to compare the occurrence of higher liver tests in an adult population who self-administer CBD to the average and general adult population.

Studies concluded that people who self-administer CBD for various ailments did not appear to have increased results in their liver tests. However, the underlying diseases or medicines taken to treat these conditions could be the main source of the anomalies. Self-medication of CBD, when taken in controlled amounts, was not linked to clinical liver damage in adults.

Is CBD Good For Fatty Liver?

All mammals have an endocannabinoid system consisting of (CB1 and CB2) receptors. CBD interacts with ECS and helps in mood, appetite, sleep, and memory regulation. The body naturally produces endocannabinoids. These molecules bind to the C1 and C2 receptors, found in the central and peripheral nervous systems, respectively.

The body’s ability to stabilize and adapt happens in the ECS. The ECS controls homeostasis to maintain balance. Moreover, this network regulates the equilibrium of the body’s many systems and organs, including the liver.

When the liver gets injured, inflamed, or malfunctions, the body’s response is to produce more endocannabinoids. The ECS’s activity is mainly associated with a healthy liver. In fact, the ECS components in the liver are low in concentration.

Emerging evidence indicates that cannabinoids play a key role in fatty liver regulation. They are mediated by cannabinoid receptor activation.

While researchers are still looking into how CBD interacts with the ECS, most results are mainly based on assumptions. But they believe that the endocannabinoids take time to break down. Hence, it enhances the functions of these neuroreceptors in the body.

Can CBD Oil Help People With Liver Cancer?

Studies about cannabis and its efficacy in liver cancer reveal that it can deter tumor cells from spreading. Moreover, scientists revealed that it could destroy cancer cells while preserving healthy cells. CBD Oil is used in various ways to help fight liver cancer and prevent cancer growth. First, it acts as an anti-metastatic agent, inhibiting the development of reserved tumor masses in the liver. Second, it inhibits the growth of new blood vessels, which aid cancer progression.

CBD causes pre-programmed cell death. Scientists discovered this ability while studying the effects of CBD in animals. These anti-cancer features apply to both CBD and THC.

Cannabidiol For Viral Hepatitis

Viral hepatitis B (HBV) and hepatitis C (HCV) are grave public health concerns worldwide. Both viruses induce severe liver damage if left untreated, resulting in cirrhosis and cancer. Unlike HBV, which has a vaccination, HCV does not. The potential of drug resistance and the high cost of existing medicines led to the discovery and development of cost-effective medications.

With the recent spike in interest in medical cannabis CBD, scientists kept pushing to discover more of its benefits. Researchers are looking into analyzing and verifying the therapeutic potential of CBD liver function.

They found CBD to limit the multiplication of the hepatitis C virus by nearly 90% in a study published in the Journal of Pharmacognosy Research. They concluded from this research that CBD has the potential to be further researched as a treatment for viral hepatitis. Moreover, people can use it as a combination therapy with existing medications.

CBD For Hepatic Ischemia

Hepatic ischemia is a prevalent complication of liver surgery and transplant. It causes the liver to be severely inflamed and can even lead to transplant and rejection-related mortality. Moreover, oxidative stress can aggravate the patient’s condition.

Scientists found that CBD has antioxidative properties. Further, it also has anti-inflammatory effects. Thus, it could help to reduce inflammation and protect the liver from oxidative damage. Researchers found that CBD efficiently reduced inflammation and oxidative stress during experiments in labs. Not only that, but it also caused an increase in malignant cell death in the liver. According to other studies, when scientists treated rats with hepatic ischemia with CBD, it resulted in a considerable reduction in liver damage.

CBD For Liver Encephalopathy

Hepatic encephalopathy is defined by psychological disturbances that occur due to liver malfunction. Personality changes, confusion, and movement issues are just a few signs. In severe circumstances, it can lead to a coma.

This condition is usually caused by inflammation. Scientists conducted a study on mice with hepatic encephalopathy to determine the therapeutic effects of CBD oil. They found that CBD oil restored neurological function and cognitive capabilities. CBD also helps restore liver function and regulates the overall level of liver enzymes by lowering ammonia levels in the blood.

CBD For Autoimmune Hepatitis

Inflammation of the liver causes autoimmune hepatitis to an already compromised immune system. The TRP (transient receptor potential) is a set of membrane proteins involved in transmitting various chemical and physical signals.

Studies report that when TRPV1 is activated, it lowers the inflammation of the liver by activating myeloid-derived suppressor cells (MDSCs). Hence, blocking the inflammation leads to autoimmune hepatitis.

According to research, CBD causes the TRPV1 receptor to activate. Not only that, but it also helps in reducing inflammation and pain due to the proliferation of T cells. It is safe to say that CBD can help prevent and treat autoimmune hepatitis.

Hemp For Alcohol-Induced Liver Fibrosis

Liver fibrosis happens due to constant liver damage caused by overconsumption of alcohol. Chronic alcohol abuse eventually leads to liver cirrhosis.

Scientists found that CBD has anti-fibrosis characteristics. It hinders the production of collagen by cells that cause fibrosis. Moreover, it can also help to counteract the effects of alcohol-induced liver damage.

Does CBD Oil Affect Liver Enzymes?

There have been conflicting results of studies on CBD oil’s effect on liver function. According to one study, 10% of the participants had increased levels of liver enzymes and had to quit using CBD as a result. Scientists found that CBD improves liver function in other trials. To avoid any possible CBD-drug interactions and minimize liver stress, individuals with liver disorders should limit their use of over-the-counter (OTC) drugs. If the individual does not exceed a dose of 20 mg CBD/kg/day, CBD is typically safe for liver function.

Dosage Of CBD For Correct Liver Functioning

There is no right amount of dosage when it comes to CBD and liver. Most human medical trials that suggested precise CBD dosages have been conducted on anxiety, chronic disorders including epilepsy, and multiple sclerosis models. There is yet to be a clinical investigation that looks into CBD’s effects on various stages of liver diseases. Moreover, researchers have yet to determine a proper dosage for this condition.

The ideal dosage of CBD for each person is defined by several factors: weight, age, and gender. Moreover, you also have to consider the intensity of the symptoms, one’s metabolic rate, and experience with CBD products.

The best method is, to begin with a minimal dose and slowly increase it until you achieve the desired relief. We suggest starting with 5 to 10 mg of CBD and evaluating the results for one week. If you believe the amount is inadequate, you can increase the dose to 5 mg and continue for another week, reevaluating the outcomes.

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It would be best to ask a physician to measure the most suitable dosage range for you. Also, they should assist you in avoiding possible drug interactions if you are using medication.

Benefits And Side Effects Of Hemp For Liver

CBD can help reduce feelings of anxiety and sadness, control PTSD symptoms, and ease chronic pain. Moreover, it offers protection against some neurological disorders. General enhanced brain, heart, and healthy skin are possible CBD oil advantages. However, researchers need to conduct more studies to figure out how CBD affects these ailments.

On the other hand, the evidence from consumers that the benefits of CBD are many. Further, CBD may provide these benefits without the euphoric symptoms associated with marijuana. Even though some CBD products contain trace levels of THC, these amounts are trivial compared to the amount required to feel high.

CBD oil may be a helpful approach to improving your quality of life. If you are looking for a way to relax after a hectic day at work, CBD may relieve that stress. If you seek treatment for chronic pain and muscle spasms, CBD may help reduce the sensation.

Negative Effects Of CBD

CBD offers a high level of safety. People turn to CBD as a low-risk alternative to traditional liver disease treatment methods. But, when ingested in excessive dosages, it causes a few side effects, including:

  • Dizziness
  • Gastrointestinal problems
  • Fatigue
  • Dry mouth
  • Appetite changes

Some of these adverse effects may occur due to an overdose. Also, ingesting an incorrectly labeled product with more than 0.3% THC can cause such side effects. Lastly, if one obtains CBD from low-quality hemp or is processed with harsh solvents, one will suffer from adverse reactions. When taking high-quality CBD oil daily, the mentioned adverse effects are almost non-existent.

Best CBD Oil For Liver Issues

#1. Flavored Hemp Oil By BudPop

BudPop offers two varieties of CBD oil that include peppermint tincture and natural CBD. The tincture comes in a 1 fl oz glass dropper bottle. Each bottle contains 1,500 mg of CBD and 50 mg of CBD per serving. Further, ingestion is simple because all you need to do is place a few drops of the product under your tongue.

The tincture contains no synthetic compounds or preservatives. It is organically flavored with peppermint and has been lab certified for purity and strength. The tincture is composed of CBD from organic hemp, natural peppermint oil, terpenes, sucralose, and water. Each bottle contains 30 servings which can last you a month or more depending on usage.

BudPop CBD uses hemp farmed in the United States. Both peppermint and natural CBD tinctures contain natural terpenes for that smooth and rich taste. You can use the dropper to measure the amount of oil. Drop the oil under your tongue and hold it for at least 20 seconds. It may take some time for the oil to take effect, and when it does, you may experience a pleasant and soothing calm. You can also change the dose by ingesting a different quantity of drops.

BudPop recommends keeping the tincture in a cool, dry place away from sunlight. They back their products with a 30-day money-back guarantee. Hence, you can return them if you feel that the product is not working for you. However, they only allow returns for unopened products.

#2. Full-Spectrum CBD Oil By Exhale Wellness

Exhale Wellness offers a full-spectrum CBD oil. Its oils are non-GMO, free from preservatives, organic, and made of 100% natural ingredients. Exhale Wellness’s full-spectrum CBD oil comes in a clean glass dropper bottle, and it is available in 600 mg and 1,200 mg. Exhale Wellness offers premium hemp products that are lab tested for accuracy and derived from legal complaint hemp. All products are not tested on animals and are cruelty-free. Exhale Wellness offers a 30-day money-back guarantee and 20% off on the first purchase.

How To Consume CBD Tinctures

Most manufacturers sell CBD oils in 30 ml glass dropper vials, which contain around 30 doses of CBD. You can prolong the shelf life by keeping it in a dry, cold, and dark environment away from light. Many CBD users agree that consuming a tincture is one of the simplest techniques to ingest CBD oil due to its easy packing. You only need a few drops sublingually and wait for them to work.

The best method for ingesting CBD oil is sublingual. Hold the oil below your tongue for at least 20 seconds before taking your dose. While the oil is resting under your tongue, the CBD is absorbed by the thin mucus membranes. It avoids digestion and rapidly enters the circulatory system. Holding the oil under your tongue allows the oil to permeate your system quickly. You may feel the results sooner if you keep it under your tongue rather than ingest it.

However, some users may need extra time to select their ideal dosage, and some users may dislike the taste of oils. The natural bitterness of hemp compounds most likely causes it. That is why many companies use various flavors to cover the taste of hemp. Some consumers also report a burning or tingling sensation while using the oil. While this is not hazardous, it may cause CBD users to seek out different methods of consuming the product.

FAQs: CBD Oil & Liver Functioning

#1. How Long Would It Take For CBD Oil To Work?

Several factors determine the time consumed for CBD oil to work. Because everyone is different, an individual’s biology can influence, to some extent, how long it takes for CBD oil to take its optimum effect. You must consider the person’s metabolic rate, age, fitness level, and tolerance.

First, hold the CBD oil under your tongue to allow the oil to enter your mucous membranes. It may take approximately half an hour to know the effect of CBD oil in this manner. It is one of the easiest ways to experience the benefits of CBD oil.

Then there is the alternative of simply swallowing the CBD oil or mixing it with food or drink. You can take it along with your food or drink instead of using it sublingually, but you will have to wait for the effects to kick in. It is totally up to you to decide how to use CBD oil based on your preferences and needs.

#2. Why Should We Use CBD Tinctures?

CBD tinctures can be effective in a variety of ways. CBD products may be pretty efficient at relieving pain in the body. The ECS system is a unique mechanism in the human body. It helps the body govern many functions and activate specific immunological responses. Moreover, this system regulates bodily activities like eating, pain sensation, and sleep.

#3. Isolate, Broad-Spectrum, And Full-Spectrum CBD Oil – What Is Their Difference?

Full-spectrum CBD contains all of the components present in hemp plants, including THC, the chemical that causes a high. In broad-spectrum CBD, the hemp plant includes a number of components, including CBD, but no THC. While you will still receive many benefits, they will be less intense owing to the lack of THC. Isolate CBD is the purest form of CBD. It is purely made of CBD, and no other compounds are present.

#4. What Are The Benefits Of Buying BudPop CBD Oil?

BudPop uses hemp grown in the USA. The hemp used in their oils is organic and free from toxins and heavy metals. The BudPop CBD tinctures are available in two flavors. It is potent and contains legal amounts of THC. Moreover, BudPop offers Certificates of Analysis for its goods, including detailed information regarding their effectiveness, durability, and purity. BudPop provides quick and easy shipping; they will pack and ship your orders immediately and at no extra expense.

Final Thoughts: Does CBD Prevent Liver Illnesses?

Research has shown that CBD effectively treats various severe liver illnesses, including fatty liver disease, liver cancer, fibrosis, and cirrhosis. High-quality CBD oils offer lots of benefits. Its effectiveness may be therapeutic in various ailments involving liver malfunction. Moreover, it may help to substitute long-term use of certain drugs. A high dosage can cause liver toxicity. Hence, we advise patients to seek medical advice before introducing CBD into their lifestyle. Discuss the dosage and set the best time timetable to avoid probable drug interactions.

CBD and Liver Damage: How Does It Affect Liver Functions?

As the use of CBD is booming across the United States, people have become more aware of its health benefits as well as potential risks associated with the consumption of CBD products.

One recent study has sparked concerns among CBD users when it comes to liver function. While the study did show that extremely large amounts of CBD can damage the liver, the news coverage that warned about the potential risk of taking CBD failed to put the study into context.

It goes without saying that CBD — like any supplement or medication — does have side effects, including dose-dependent danger to liver health. However, while users using the peak-tested dosages should have their liver enzymes in check, the vast majority of people can safely use CBD without worrying about a negative impact on their liver function.

In this article, we’ll explain the context of the said study and provide evidence supporting the health benefits of regular doses of CBD for liver health.

Let’s resolve the doubts surrounding the topic of CBD and liver function.

Is CBD Oil Bad for Your Liver?

CBD has a remarkably good safety profile. Researchers have tested the efficacy and safety of CBD in humans using doses as high as 1,500 mg – 3000 mg CBD daily.

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With 1,500 mg of CBD taken for a six-week period, no dangerous side effects were observed (1).

However, the recent 2019 study on mice showed that high doses of CBD can damage the liver — causing widespread sensation all over the media.

The study has also garnered attention among CBD skeptics who have been trying to undermine the therapeutic potential of CBD looking for at least one serious side effect.

Now, we’re not saying CBD doesn’t have any side effects — it does, like any other health supplement — but should you actually worry about your liver when you use normal doses?

Let’s shed some light on the infamous study on mice.

The Study on CBD and the Liver of Mice

According to researchers from the University of Arkansas, who investigated the effects of treatments of various doses of CBD on a group of 8-week-old mice, the study addressed the problem of a “lack of comprehensive toxicological studies devoted to CBD safety that are critical for further marketing of CBD and CBD-containing products.” (2)

The majority of mice tolerated the CBD, but those administered the highest doses — an equivalent to 200 mg of CBD in humans — showed clear symptoms of liver toxicity, as reported by the researchers.

In addition, repeated doses of a smaller amount of CBD (50 mg) also showed signs of liver damage and swelling.

Here’s what the authors wrote at the end of the paper:

“Although (a dose of) 200 mg is not applicable to most real-life scenarios, it does provide critical information regarding the potential consequences of CBD overdose as well as for doses needed for further subchronic and chronic toxicity studies.”

However, one of the caveats of this study was that it tested the maximum recommended daily dosage for humans. While all mammals share the same endocannabinoid system, mice and humans are different physiologically. The size of the liver is just one of the many variables that should be taken into consideration when evaluating the safety of CBD in human subjects.

Experts Say It’s About the Dosage

Although the results of the above study sound potentially discouraging, most experts say there’s no need to freak out over the impact of CBD on the liver. While experts stress the importance of knowing the risks of taking health supplements, the amount of CBD the mice were exposed to is much higher than what most humans take.

According to Dr. Diana Martins-Welch, attending physician in palliative medicine at Northwell Health in New Hyde Park, New York, there are certain quantities in which CBD may not be safe for humans; CBD also isn’t always more effective in high doses.

“Many people know that taking too much ibuprofen or Tylenol can have detrimental consequences. CBD is no different. Generally speaking, therapeutic CBD doses range from 0.5 mg/kg/day to 20 mg/kg per day. This study in mice used significantly higher doses of CBD (in relation to their weight) than what is usually taken for therapeutic benefit in humans.” Martins-Welch explained.

Martins-Welch also said that therapeutic-range CBD is generally safe, and while toxicity at extremely high doses is a concern, it is no different than with other supplements or medicines.

Therefore, what the study essentially showed was how people need to be careful if they take high doses of CBD daily.

Human studies that have examined the safety of different doses of CBD have found no negative effects at the recommended maximum daily dosage of 20 mg/kg. This dosage was taken from the trial of Epidiolex, a CBD-based pharmaceutical for treatment-resistant seizures. To put that in context, an individual weighing 150 pounds would need to take over 1,300 mg of CBD per day, which is way above what most people take (10–80 mg daily).

Effects of CBD On the Liver

Okay, so now you know that extremely high doses of CBD may cause liver toxicity when taken regularly. You also know that it’s impossible to trigger toxicity with normal doses of CBD oil.

Now it’s time to ask a different question: what positive effects does CBD have on the liver?

There are plenty, to be honest.

In the next section, we elaborate on the potential therapeutic uses of CBD oil for liver function.

CBD Oil for Fatty Liver

The endocannabinoid system (ECS) is found in all mammals and consists of receptors (CB1 and CB2) endogenous cannabinoids, and enzymes that facilitate their production or break them down.

The ECS is responsible for regulating many of our homeostatic control processes. In other words, this network controls the balance of various systems and organs in the body, including the liver.

When the liver gets damaged, inflamed, or dysfunctional, the body starts to release more endocannabinoids to solve the problem. A healthy liver is correlated with a modest activity of the endocannabinoid system. In fact, this particular organ has a relatively low concentration of the ECS components.

However, inflammation in the liver causes the endocannabinoid to be very active in this area. Unfortunately, an overactive endocannabinoid system plays a role in the development of fatty liver disease (3).

CBD is the modulator of CB1 and CB2 receptors. In simple English, it keeps them from going crazy by stopping the compounds that make these receptors go haywire in the liver.

CBD ensures the proper functioning of a system that balances us. So while it won’t cure fatty liver disease, it can prevent its development. And should the disease occur, it may be able to reduce the inflammation in the organ, protecting it against further damage.

CBD Oil for Liver Cancer

To this day, studies on cannabinoids and their effect on liver cancer show that cannabinoids can both prevent the dividing of tumor cells and kill cancer cells while protecting the healthy ones. Besides stopping cancer proliferation, there are several mechanisms CBD uses to help tackle liver cancer.

First, it provides anti-metastatic actions, preventing distant tumor masses from forming in the liver.

Second, it prevents the formation of blood vessels that facilitate tumor growth.

And last but not least, CBD triggers apoptosis, which is programmed cell death. Researchers have found this ability during animal and laboratory models; these properties apply to both CBD and THC (4).

Although no study has yet analyzed the effects of CBD on liver cancer in humans, current research supports the use of cannabinoids as a complementary therapy as well as a means of reducing the side-effects of chemotherapy and radiation.

CBD Oil for Viral Hepatitis

Viral hepatitis is one of the most common infectious diseases characterized by inflammation. It is also a great contributor to many deaths globally. Hepatitis can lead to the formation of liver cancer and cirrhosis.

CBD has been shown to have therapeutic effects on the models of viral hepatitis, especially Hepatitis C. According to a study published in the journal Pharmacognosy Research, CBD was shown to inhibit the replication of hepatitis C virus by almost 90% (5).

The inhibitory effects on the virus were dose-dependent but showed little toxicity towards the cells. CBD was also found to induce death in the infected cells containing the hepatitis B virus, although it did not inhibit the virus itself.

Finally, the attenuation of the immune response through the interaction with the ECS in the immune cells may help in alleviating autoimmune hepatitis.

CBD Oil for Hepatic Ischemia

Ischemia is a very common injury that occurs as an aftermath of liver surgeries and liver transplantations. It involves major inflammation and is responsible for deaths in the case of transplants and rejections. Oxidative stress can worsen the condition.

CBD is known for its anti-inflammatory and antioxidative properties, so it could be useful in reducing the inflammatory response and protecting the liver against oxidative damage. In experimental models, CBD effectively reduced inflammation, oxidative stress, and promoted the death of malignant cells in the liver.

Other studies found that administration of CBD to the rats with ischemic liver injury resulted in a significant reduction of liver damage associated with the condition (6).

CBD Oil for Hepatic Encephalopathy

Hepatic encephalopathy is characterized by psychological changes resulting from the damage and failure of the liver. Some symptoms include altered personality, confusion, movement problems, etc. It can lead to a coma in severe cases.

Inflammation is one of the main causes of hepatic encephalopathy. A study conducted on mice models of hepatic encephalopathy reported positive effects. The research team observed that applying CBD to mice could restore the neurological functions and cognitive performance in the mice. CBD also reduced the levels of ammonia in the blood, helping restore liver function and normalize the number of liver enzymes (7).

CBD Oil for Autoimmune Hepatitis

Autoimmune hepatitis results from a weakened immune system that attacks the liver. Again, inflammation is the key player in the development of this disease. One study has reported that the activation of TRPV1 vanilloid receptor — part of the ECS — lowers inflammation by activating myeloid-derived suppressor cells (MDSCs). These cells, in turn, block inflammation and the development of autoimmune hepatitis.

CBD happens to activate the TRPV1 receptors, not only reducing the pain but also inhibiting the proliferation of T cells that trigger inflammation (8). Therefore, it’s within reason to assume that CBD could be used for the prevention and treatment of liver inflammation and autoimmune hepatitis.

CBD Oil for Alcohol-Induced Liver Injury

Liver fibrosis is a common result of chronic liver damage caused by binge drinking. It can lead to cirrhosis and liver failure.

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CBD has been shown to have anti-fibrosis properties by eliminating cells that secrete collagen and cause fibrosis. It can also reverse alterations in the liver associated with alcohol-induced injury (9).

Does CBD Oil Increase Liver Enzymes?

The studies performed on how CBD affects liver function have brought conflicting results.

For example, one study found that 10% of the subjects had higher levels of liver enzymes and had to stop using CBD for this reason. Other studies suggest that CBD can improve liver function. Since CBD is metabolized by the liver — as shown by the studies done on Epidiolex — patients with liver diseases should limit over-the-counter (OTC) medications to avoid potential CBD-drug interactions and reduce the stress experienced by the liver.

Long story short, CBD is generally safe for your liver enzymes if you don’t exceed the dose of 20 mg CBD/kg/day.

CBD Dosage for Liver

If you’re looking to improve liver function with CBD oil, you’re probably wondering how much CBD is enough to provide relief from pain and inflammation and to keep this organ healthy.

Unfortunately, there are no official dosage recommendations when it comes to CBD and the liver. Most clinical trials that suggest specific dosages of CBD have been performed on anxiety, chronic disorder such as epilepsy, and multiple sclerosis models in humans. No clinical study has yet investigated the efficacy of different doses of CBD on the symptoms of liver disease.

The optimal amount of CBD for each individual depends on factors such as weight, metabolism, age, gender, the severity of symptoms, and previous history with CBD products.

The best approach you can take is to start low and gradually increase the dose until you experience the desired relief. We suggest that you start with 5–10 mg CBD and try it out for one week, monitoring the effects. If you deem the dose insufficient, add another 5 milligrams and continue for another week, reassessing the results.

We also encourage you to consult a doctor knowledgeable about CBD and cannabis in general. A qualified physician should help you avoid potential interactions with other medications and determine the right dosage range.

Side Effects of CBD

As mentioned earlier in the article, CBD has an excellent safety profile. People turn to CBD because it’s a low-risk alternative to conventional treatment options for liver disease. That being said, it has a few relatively mild effects when consumed in high doses, including:

  • Dry mouth
  • Changes in appetite
  • Dizziness
  • Sedation
  • Diarrhea

Some of these side effects may result from consuming a mislabeled product that has more than 0.3% THC, or one that has been sourced from poor-quality hemp or extracted with aggressive solvents. When you take high-quality CBD oil at regular doses, the above side effects are nearly non-existent.

However, there’s a risk of potential drug interactions, as CBD is metabolized by the same group of enzymes that process active ingredients in pharmaceuticals. As an inhibitor of those enzymes, CBD can lead to either subtherapeutic effects or substance toxicity when taken along with medications for liver function. That’s why we recommend consulting a doctor before adding CBD oil to your routine.

CBD Oil and Liver: Bottom Line

The liver is a fundamental detoxifying organ that performs many important functions to keep the body in the optimum state. It plays a role in digestion, detoxification, drug metabolism, and more.

There are many diseases affecting the liver as it is constantly exposed to environmental damage from pollutants, alcohol, drugs, medications, etc. It is also prone to autoimmune diseases.

CBD has been shown to have therapeutic effects in many major liver diseases, including viral hepatitis, fatty liver disease, ischemia-reperfusion injury, cirrhosis, fibrosis, and liver cancer.

High-quality full-spectrum CBD oil could be beneficial in a range of disorders that involve liver dysfunction and might help replace the long-term use of other medications.

Although extremely high doses of CBD taken daily have been associated with liver toxicity, so have other supplements and medications. Therefore, it’s best to keep your use of CBD within reason. Doses as high as 20 mg of CBD per kg don’t pose a threat to your liver’s health, as tested in the clinical trial of Epidiolex, a CBD-based anti-seizure medication.

Patients should seek medical consultation before incorporating CBD into their routine to discuss the dosage and establish the right time schedule to avoid potential interactions with other medications.

References:

  1. Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
  2. Ewing, Laura E et al. “Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.” Molecules (Basel, Switzerland)vol. 24,9 1694. 30 Apr. 2019, doi:10.3390/molecules24091694
  3. Purohit, Vishnudutt et al. “Role of cannabinoids in the development of fatty liver (steatosis).” The AAPS journal vol. 12,2 (2010): 233-7. doi:10.1208/s12248-010-9178-0
  4. Vara, D et al. “Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.” Cell death and differentiation vol. 18,7 (2011): 1099-111. doi:10.1038/cdd.2011.32
  5. Lowe, Henry I C et al. “Potential of Cannabidiol for the Treatment of Viral Hepatitis.” Pharmacognosy research vol. 9,1 (2017): 116-118. doi:10.4103/0974-8490.199780
  6. Fouad, Amr A, and Iyad Jresat. “Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats.” European journal of pharmacology vol. 670,1 (2011): 216-23. doi:10.1016/j.ejphar.2011.08.048
  7. Avraham, Y et al. “Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice.” British journal of pharmacology vol. 162,7 (2011): 1650-8. doi:10.1111/j.1476-5381.2010.01179.x
  8. Muller, Chanté et al. “Cannabinoid Ligands Targeting TRP Channels.” Frontiers in molecular neuroscience vol. 11 487. 15 Jan. 2019, doi:10.3389/fnmol.2018.00487
  9. Zurier, Robert B, and Sumner H Burstein. “Cannabinoids, inflammation, and fibrosis.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 30,11 (2016): 3682-3689. doi:10.1096/fj.201600646R
Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

Observed Impact of Long-term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults

Introduction: Previous studies have suggested that prescribed cannabidiol (CBD) products may cause elevations in liver tests (LT). This study compared the prevalence of elevated LT in an adult population self-administering CBD with the normal and general adult population prevalences. Materials and Methods: Adults 18-75 years of age across the United States taking CBD orally for a minimum of 30 days were recruited from 12 individual CBD product companies in this decentralized, observational study and sent their standard CBD regimen from the company of their choice. An app-based, 21CFR Part 11 decentralized clinical study platform (ValidCare Study) was used to securely automate consent inclusion/exclusion criteria and collect all the data for this study, including: demographic information, medical history, reasons for taking, dosage, current medications dosage, adverse effects, and efficacy. At the end of 30 days, LTs were obtained. Follow-up LTs were offered to all individuals with elevated alanine transaminase (ALT) values. Results: A total of 28,121 individuals were invited to participate in this study, 1475 enrolled, and 839 (female: 65.3%, male: 34.7%) completed the study. Full-spectrum hemp oil was used by 55.7%, CBD-isolate by 40.5%, and broad spectrum by 3.8%. The mean±SD daily dose of CBD was 50.3+40.7 mg. The prevalence of elevated ALT was 9.1%, aspartate aminotransferase (AST) 4.0%, alkaline phosphatase 1.9%, total bilirubin 1.7%, with 85.5% of the ALT elevations 3× ULN. The prevalence of ALT and AST elevations (9.1% and 4.0%) were not significantly different from known adult general population prevalences (8.9% and 4.9%). There was no significant association between CBD dosage and LT values. Thirty-three individuals with elevated ALT levels had follow-up LT performed with 21 having normal LT, 8 having the same severity of ALT elevation, and 4 having an increase in severity, 1 of which ultimately became normal. Conclusions: Self-medication of CBD does not appear to be associated with an increased prevalence of LT elevation and most of the LT elevations are likely due to the conditions/medications for which the individuals are taking CBD.

Keywords: ALT; AST; CBD; LT; cannabidiol; liver function test.

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